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What was the first hyaluronic acid product approved by the FDA for dermal filling?

  1. Juvederm

  2. Restylane

  3. Belotero

  4. Radiesse

The correct answer is: Restylane

Restylane is recognized as the first hyaluronic acid product to receive FDA approval for use as a dermal filler. This landmark approval, granted in 2003, marked a significant advancement in aesthetic medicine, allowing practitioners to offer patients a safe and effective option for facial volume restoration and wrinkle treatment. The formulation of Restylane consists of hyaluronic acid, a naturally occurring substance in the body that helps retain moisture and provide volume, thereby enhancing the skin's appearance when injected. Other products, including Juvederm, Belotero, and Radiesse, were introduced later and have distinct formulations or active components. For instance, Juvederm, which is also hyaluronic acid-based, received FDA approval a few years after Restylane, while Radiesse is primarily composed of calcium hydroxylapatite and offers a different mechanism of action for volume restoration. Understanding the historical context of these products can help in comprehending the evolution of dermal fillers and their wide array of applications in the field of aesthetics.